Edwin Encarnacion hit a three-run, walk-off home run in the ninth inning and the Toronto Blue Jays beat Milwaukee 7-4 on Wednesday, handing the Brewers their third straight loss.
Jose Bautista and Juan Francisco also connected for the Blue Jays, who have hit a major league high 113 home runs this season.
Facing Will Smith (1-1), Jose Reyes led off the ninth with a double that left fielder Elian Herrera dove for but couldn't handle.
Melky Cabrera was intentionally walked and Brandon Kintzler came on to face Anthony Gose, who failed to advance the runners with a bunt when Reyes was forced at third.
Darin Mastroianni struck out but Encarnacion ended it with a drive into the second deck in left, his 26th.
Encarnacion is tied for the major league lead with White Sox rookie Jose Abreu and Baltimore's Nelson Cruz.
Casey Janssen (3-0) worked one inning for the win.